Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity

• Үндсэн зохиолчид: Kirill Kirsanov (Зохиогч), Timur Fetisov (Зохиогч), Elena Antoshina (Зохиогч), Lubov Trukhanova (Зохиогч), Tatiana Gor'kova (Зохиогч), Olga Vlasova (Зохиогч), Irina Khitrovo (Зохиогч), Ekaterina Lesovaya (Зохиогч), Nataliya Kulbachevskaya (Зохиогч), Tatiana Shcherbakova (Зохиогч), Gennady Belitsky (Зохиогч), Marianna Yakubovskaya (Зохиогч), Vytas Švedas (Зохиогч), Dmitry Nilov (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

7-Methylguanine (7-MG) competitively inhibits the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) and RNA-modifying enzyme tRNA-guanine transglycosylase (TGT) and represents a potential anticancer drug candidate. Furthermore, as a natural compound, it could escape the serious side effects chara...