Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity

• Main Authors: Kirill Kirsanov (Author), Timur Fetisov (Author), Elena Antoshina (Author), Lubov Trukhanova (Author), Tatiana Gor'kova (Author), Olga Vlasova (Author), Irina Khitrovo (Author), Ekaterina Lesovaya (Author), Nataliya Kulbachevskaya (Author), Tatiana Shcherbakova (Author), Gennady Belitsky (Author), Marianna Yakubovskaya (Author), Vytas Švedas (Author), Dmitry Nilov (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

7-Methylguanine (7-MG) competitively inhibits the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) and RNA-modifying enzyme tRNA-guanine transglycosylase (TGT) and represents a potential anticancer drug candidate. Furthermore, as a natural compound, it could escape the serious side effects chara...