Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors

Chronic lymphocytic leukemia is a common form of leukemia and is dependent on growth-promoting signaling via the B-cell receptor. The Bruton tyrosine kinase (BTK) is an important mediator of B-cell receptor signaling and the irreversible BTK inhibitor ibrutinib can trigger dramatic clinical response...

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Bibliographic Details
Main Authors: Rachael Arthur (Author), Beatriz Valle-Argos (Author), Andrew J. Steele (Author), Graham Packham (Author)
Format: Book
Published: Open Exploration Publishing Inc., 2020-06-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
Copy 1 Available