Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

• Main Authors: Michael R. DiGruccio (Author), Alex M. Mawla (Author), Cynthia J. Donaldson (Author), Glyn M. Noguchi (Author), Joan Vaughan (Author), Christopher Cowing-Zitron (Author), Talitha van der Meulen (Author), Mark O. Huising (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Complex local crosstalk amongst endocrine cells within the islet ensures tight coordination of their endocrine output. This is illustrated by the recent demonstration that the negative feedback control by delta cells within pancreatic islets determines the homeostatic set-point for plasma...