Decreased Levels of Chaperones in Mucopolysaccharidoses and Their Elevation as a Putative Auxiliary Therapeutic Approach

• Main Authors: Magdalena Żabińska (Author), Lidia Gaffke (Author), Patrycja Bielańska (Author), Magdalena Podlacha (Author), Estera Rintz (Author), Zuzanna Cyske (Author), Grzegorz Węgrzyn (Author), Karolina Pierzynowska (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mucopolysaccharidoses (MPS) are rare genetic disorders belonging to the lysosomal storage diseases. They are caused by mutations in genes encoding lysosomal enzymes responsible for degrading glycosaminoglycans (GAGs). As a result, GAGs accumulate in lysosomes, leading to impairment of cells, organs...