Decreased Levels of Chaperones in Mucopolysaccharidoses and Their Elevation as a Putative Auxiliary Therapeutic Approach

• Автори: Magdalena Żabińska (Автор), Lidia Gaffke (Автор), Patrycja Bielańska (Автор), Magdalena Podlacha (Автор), Estera Rintz (Автор), Zuzanna Cyske (Автор), Grzegorz Węgrzyn (Автор), Karolina Pierzynowska (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2023-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Mucopolysaccharidoses (MPS) are rare genetic disorders belonging to the lysosomal storage diseases. They are caused by mutations in genes encoding lysosomal enzymes responsible for degrading glycosaminoglycans (GAGs). As a result, GAGs accumulate in lysosomes, leading to impairment of cells, organs...