Decreased Levels of Chaperones in Mucopolysaccharidoses and Their Elevation as a Putative Auxiliary Therapeutic Approach

• প্রধান লেখক: Magdalena Żabińska (লেখক), Lidia Gaffke (লেখক), Patrycja Bielańska (লেখক), Magdalena Podlacha (লেখক), Estera Rintz (লেখক), Zuzanna Cyske (লেখক), Grzegorz Węgrzyn (লেখক), Karolina Pierzynowska (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2023-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Mucopolysaccharidoses (MPS) are rare genetic disorders belonging to the lysosomal storage diseases. They are caused by mutations in genes encoding lysosomal enzymes responsible for degrading glycosaminoglycans (GAGs). As a result, GAGs accumulate in lysosomes, leading to impairment of cells, organs...