Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation

• Main Authors: Junzhong Lai (Author), Xuan Luo (Author), Shuoran Tian (Author), Xing Zhang (Author), Shanlu Huang (Author), Hanze Wang (Author), Qiumei Li (Author), Shaoli Cai (Author), Qi Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic lupus erythematosus. Compound C (also known as...