Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic lupus erythematosus. Compound C (also known as...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Frontiers Media S.A.,
2020-02-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_72c0f019e2d746e28c4a2ed8b9cfdcd3 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Junzhong Lai |e author |
| 700 | 1 | 0 | |a Junzhong Lai |e author |
| 700 | 1 | 0 | |a Xuan Luo |e author |
| 700 | 1 | 0 | |a Xuan Luo |e author |
| 700 | 1 | 0 | |a Shuoran Tian |e author |
| 700 | 1 | 0 | |a Shuoran Tian |e author |
| 700 | 1 | 0 | |a Xing Zhang |e author |
| 700 | 1 | 0 | |a Xing Zhang |e author |
| 700 | 1 | 0 | |a Shanlu Huang |e author |
| 700 | 1 | 0 | |a Shanlu Huang |e author |
| 700 | 1 | 0 | |a Hanze Wang |e author |
| 700 | 1 | 0 | |a Hanze Wang |e author |
| 700 | 1 | 0 | |a Qiumei Li |e author |
| 700 | 1 | 0 | |a Qiumei Li |e author |
| 700 | 1 | 0 | |a Shaoli Cai |e author |
| 700 | 1 | 0 | |a Shaoli Cai |e author |
| 700 | 1 | 0 | |a Qi Chen |e author |
| 700 | 1 | 0 | |a Qi Chen |e author |
| 245 | 0 | 0 | |a Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation |
| 260 | |b Frontiers Media S.A., |c 2020-02-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2020.00088 | ||
| 520 | |a Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic lupus erythematosus. Compound C (also known as Dorsomorphin) has been annotated as a potent and reversible inhibitor for AMPKs as well as ALK protein kinases. Here, we report a new function of Compound C which can suppress dsDNA-dependent type I interferon induction. These effects were not dependent on the activities of AMPK proteins. In vitro assays and liquid chromatograph-mass spectrometry data show that Compound C has the capability of reducing cGAMP accumulation, suggesting that Compound C may function as a modulator involved in the cGAS-STING-mediated DNA sensing pathway. Furthermore, Compound C is able to rescue the autoimmune phenotypes in a mouse model carrying the Trex1 gene deficiency. These data demonstrate a new and inverse correlation between Compound C and type I interferon production in response to dsDNA signaling. | ||
| 546 | |a EN | ||
| 690 | |a compound C | ||
| 690 | |a dorsomorphin | ||
| 690 | |a cGAS | ||
| 690 | |a cGAMP | ||
| 690 | |a DNA sensing | ||
| 690 | |a type I interferon | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 11 (2020) | |
| 787 | 0 | |n https://www.frontiersin.org/article/10.3389/fphar.2020.00088/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/72c0f019e2d746e28c4a2ed8b9cfdcd3 |z Connect to this object online. |