Synthesis of niosomes of diclofenac sodium and their microscopic evaluation
Objective: Incorporation of drugs into non-ionic surfactant vesicles (niosomes) during their manufacture affords a possible method of achieving controlled release. The aim of this study was to formulate niosomes as carriers for delivery of diclofenac sodium (DCS) to achieve controlled release. Metho...
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| Main Authors: | , , , |
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| Format: | Book |
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AMMANIF,
2020-07-01T00:00:00Z.
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| Summary: | Objective: Incorporation of drugs into non-ionic surfactant vesicles (niosomes) during their manufacture affords a possible method of achieving controlled release. The aim of this study was to formulate niosomes as carriers for delivery of diclofenac sodium (DCS) to achieve controlled release. Method: Niosomes were prepared by Ether injection method using non-ionic surfactant (Span 80) and cholesterol in ratio of 1:1, the organic solvent (dichloromethane) and phosphate buffer. Results: The prepared niosomes were then evaluated for physical appearance, light microscopy, optical microscopy, transmission electron microscopy and entrapment efficiency. Conclusion: Diclofenac sodium niosomes were prepared successfully without using charge inducing surfaces and were confirmed by microscopic evaluation. |
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| Item Description: | 10.56770/jcp2020411 2521-0521 |