Repositioning of Lansoprazole as a Protective Agent Against Cisplatin-Induced Ototoxicity

• Main Authors: Eri Wakai (Author), Kenji Ikemura (Author), Toshiro Mizuno (Author), Kazuhiko Takeuchi (Author), Satoshi Tamaru (Author), Masahiro Okuda (Author), Yuhei Nishimura (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin (CDDP) is a well-known chemotherapeutic drug approved for various cancers. However, CDDP accumulates in the inner ear cochlea via organic cation transporter 2 (OCT2) and causes ototoxicity, which is a major clinical limitation. Since lansoprazole (LPZ), a proton pump inhibitor, is known to...