A monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in mice

• Ngā kaituhi matua: Joseph Ray Cepeda (Author), Nitin S Sekhar (Author), Junying Han (Author), Wei Xiong (Author), Ningyan Zhang (Author), Liping Yu (Author), Shaodong Dai (Author), Howard W. Davidson (Author), John W. Kappler (Author), Zhiqiang An (Author), Li Zhang (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Activation of T cells specific for insulin B chain amino acids 9 to 23 (B:9-23) is essential for the initiation of type 1 diabetes (T1D) in non-obese diabetic mice. We previously reported that peptide/MHC complexes containing optimized B:9-23 mimotopes can activate most insulin-reactive pathogenic T...