Polymorphisms in Plasmodium vivax Circumsporozoite Protein (CSP) Influence Parasite Burden and Cytokine Balance in a Pre-Amazon Endemic Area from Brazil.

• Main Authors: Bruno de Paulo Ribeiro (Author), Gustavo Capatti Cassiano (Author), Rodrigo Medeiros de Souza (Author), Dalila Nunes Cysne (Author), Marcos Augusto Grigolin Grisotto (Author), Ana Paula Silva de Azevedo dos Santos (Author), Cláudio Romero Farias Marinho (Author), Ricardo Luiz Dantas Machado (Author), Flávia Raquel Fernandes Nascimento (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mechanisms involved in severe P. vivax malaria remain unclear. Parasite polymorphisms, parasite load and host cytokine profile may influence the course of infection. In this study, we investigated the influence of circumsporozoite protein (CSP) polymorphisms on parasite load and cytokine profile in...