Combination of the PARPi and ARSi in advanced castration resistant prostate cancer: a review of the recent phase III trials

• Hoofdauteurs: Martina Panebianco (Auteur), Vittore Cereda (Auteur), Mario Rosario D'Andrea (Auteur)
• Formaat: Boek
• Gepubliceerd in: Open Exploration Publishing Inc., 2024-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Tumors with an impaired ability to repair DNA double-strand breaks by homologous recombination, including those with alterations in breast cancer 1 and 2 (BRCA1 and BRCA2) genes, are very sensitive to blocking DNA single-strand repair by inhibition of the poly (ADP-ribose) polymerase (PARP) enzyme....