Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies

• Main Authors: Hanan S. Anbar (Author), Mohammed I. El-Gamal (Author), Hamadeh Tarazi (Author), Bong S. Lee (Author), Hong R. Jeon (Author), Dow Kwon (Author), Chang-Hyun Oh (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of imidazothiazole derivatives possessing potential activity against melanoma cells were investigated for molecular mechanism of action. The target compounds were tested against V600E-B-RAF and RAF1 kinases. Compound 1zb is the most potent against both kinases with IC50 values 0.978 and 8.2...