Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences

• Main Authors: Wei Li (Author), Jingxue Sheng (Author), Mengqiong Xu (Author), Gia-Phong Vu (Author), Zhu Yang (Author), Yujun Liu (Author), Xu Sun (Author), Phong Trang (Author), Sangwei Lu (Author), Fenyong Liu (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA. Using murine cytomegalovirus (MCMV) as a model system, we examined...