The effect of excipient particle size on the reduction of compactibility after roller compaction

• Main Authors: Pauline H.M. Janssen (Author), Maarten Jaspers (Author), Robin Meier (Author), Timo P. Roelofs (Author), Bastiaan H.J. Dickhoff (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Developing a robust roller compaction process can be challenging, due to the diversity in process parameters and material properties of the components in a formulation. A major challenge in dry granulation is the reduction of tablet strength as a result of re-compaction of the materials. The aim of...