Molecular insights and inhibitory dynamics of flavonoids in targeting Pim-1 kinase for cancer therapy

• Main Authors: Hani A. Alhadrami (Author), Ahmed M. Sayed (Author), Hossam M. Hassan (Author), Albaraa H. Alhadrami (Author), Mostafa E. Rateb (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pim-1 kinase, a serine/threonine kinase, is often overexpressed in various cancers, contributing to disease progression and poor prognosis. In this study, we explored the potential of flavonoids as inhibitors of Pim-1 kinase using a combination of molecular docking and steered molecular dynamics (SM...