Association Between Genetic Polymorphisms of Metabolic Enzymes and Azathioprine-Induced Myelosuppression in 1,419 Chinese Patients: A Retrospective Study

• Main Authors: Zhao-Yang Chen (Author), Yang-Hui Zhu (Author), Ling-Yan Zhou (Author), Wei-Qiao Shi (Author), Zhou Qin (Author), Bin Wu (Author), Yu Yan (Author), Yu-Wen Pei (Author), Ning-Ning Chao (Author), Rui Zhang (Author), Mi-Ye Wang (Author), Ze-Hao Su (Author), Xiao-Jun Lu (Author), Zhi-Yao He (Author), Ting Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to investigate the correlation between genetic polymorphisms of azathioprine-metabolizing enzymes and adverse reactions of myelosuppression. To this end, a retrospective analysis was performed on 1,419 Chinese patients involving 40 different diseases and 3 genes: ITPA (94C&...