Exploration the Mechanism of Doxorubicin-Induced Heart Failure in Rats by Integration of Proteomics and Metabolomics Data

• Main Authors: Yu Yuan (Author), Simiao Fan (Author), Lexin Shu (Author), Wei Huang (Author), Lijuan Xie (Author), Chenghao Bi (Author), Hongxin Yu (Author), Yuming Wang (Author), Yubo Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heart failure is a common systemic disease with high morbidity and mortality worldwide. Doxorubicin (DOX) is a commonly used anthracycline broad-spectrum antitumor antibiotic with strong antitumor effect and definite curative effect. However, cardiotoxicity is the adverse reaction of drug dose cumul...