Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro

• Main Authors: Xiao-Yang Zhou (Author), Xiao-Xia Hu (Author), Chen-Chen Wang (Author), Xiang-Ran Lu (Author), Zhe Chen (Author), Qian Liu (Author), Guo-Xin Hu (Author), Jian-Ping Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment. CYP3A4 genetic polymorphisms are believed to be one of the important causes, leading to inter-individual variability in drug meta...