Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro

• المؤلفون الرئيسيون: Xiao-Yang Zhou (مؤلف), Xiao-Xia Hu (مؤلف), Chen-Chen Wang (مؤلف), Xiang-Ran Lu (مؤلف), Zhe Chen (مؤلف), Qian Liu (مؤلف), Guo-Xin Hu (مؤلف), Jian-Ping Cai (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment. CYP3A4 genetic polymorphisms are believed to be one of the important causes, leading to inter-individual variability in drug meta...