Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro

• Egile Nagusiak: Xiao-Yang Zhou (Egilea), Xiao-Xia Hu (Egilea), Chen-Chen Wang (Egilea), Xiang-Ran Lu (Egilea), Zhe Chen (Egilea), Qian Liu (Egilea), Guo-Xin Hu (Egilea), Jian-Ping Cai (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment. CYP3A4 genetic polymorphisms are believed to be one of the important causes, leading to inter-individual variability in drug meta...