Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors

• Những tác giả chính: Yaqing Zuo (Tác giả), Rongrong Li (Tác giả), Yan Zhang (Tác giả), Guochen Bao (Tác giả), Yi Le (Tác giả), Longjia Yan (Tác giả)
• Định dạng: Sách
• Được phát hành: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed to evaluate their biological activities. The results were shown that most of the target compounds existed excellent antitumor a...