Discovery of novel benzylquinazoline molecules as p97/VCP inhibitors

• Main Authors: Xiaoyi Zhang (Author), Lingna Jiang (Author), Yixin Li (Author), Qiqi Feng (Author), Xiulin Sun (Author), Yaonan Wang (Author), Ming Zhao (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Introduction: Protein p97 is an extensively investigated AAA ATPase with various cellular activities, including cell cycle control, ubiquitin-proteasome system, autophagy, and NF-κB activation.Method: In this study, we designed, synthesized and evaluated eight novel DBeQanalogs as potential p97 inhi...