Discovery of novel benzylquinazoline molecules as p97/VCP inhibitors

Introduction: Protein p97 is an extensively investigated AAA ATPase with various cellular activities, including cell cycle control, ubiquitin-proteasome system, autophagy, and NF-κB activation.Method: In this study, we designed, synthesized and evaluated eight novel DBeQanalogs as potential p97 inhi...

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Main Authors: Xiaoyi Zhang (Author), Lingna Jiang (Author), Yixin Li (Author), Qiqi Feng (Author), Xiulin Sun (Author), Yaonan Wang (Author), Ming Zhao (Author)
Format: Book
Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
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