Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

• Main Authors: Cheol Park (Author), Hee-Jae Cha (Author), Hyesook Lee (Author), Hyun Hwang-Bo (Author), Seon Yeong Ji (Author), Min Yeong Kim (Author), Su Hyun Hong (Author), Jin-Woo Jeong (Author), Min Ho Han (Author), Sung Hyun Choi (Author), Cheng-Yun Jin (Author), Gi-Young Kim (Author), Yung Hyun Choi (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the anti-cancer effect of genistein, a soy-derived isoflavone, in human bladder transitional cell carcinoma T24 cells. According to our data, genistein induced G2/M phase arrest of the cell cycle and apoptosis. Genistein down-regulated the levels of cyclin A and cyclin B1, but up-regulat...