Delineating gene-environment effects using virtual twins of patients treated with clozapine

• Main Authors: Sam Mostafa (Author), Thomas M. Polasek (Author), Chad Bousman (Author), Amin Rostami‐Hodjegan (Author), Leslie J. Sheffield (Author), Ian Everall (Author), Christos Pantelis (Author), Carl M. J. Kirkpatrick (Author)
• Format: Book
• Published: Wiley, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Studies that focus on individual covariates, while ignoring their interactions, may not be adequate for model‐informed precision dosing (MIPD) in any given patient. Genetic variations that influence protein synthesis should be studied in conjunction with environmental covariates, such as ci...