Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

• Main Authors: Viktoriya Keyer (Author), Laura Syzdykova (Author), Gulzat Zauatbayeva (Author), Aigerim Zhulikeyeva (Author), Yerlan Ramanculov (Author), Alexandr V. Shustov (Author), Zarina Shulgau (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthetic compounds, Tilorone and Cridanimod, have the antiviral activity which initially had been ascribed to the capacity to induce interferon. Both drugs induce interferon in mice but not in humans. This study investigates whether these compounds have the antiviral activity in mice and rats s...