An ultra-sensitive and easy-to-use assay for sensing human UGT1A1 activities in biological systems

• Main Authors: Ya-Di Zhu (Author), Hui-Lin Pang (Author), Qi-Hang Zhou (Author), Zi-Fei Qin (Author), Qiang Jin (Author), Moshe Finel (Author), Yi-Nan Wang (Author), Wei-Wei Qin (Author), Yin Lu (Author), Dan-Dan Wang (Author), Guang-Bo Ge (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human UDP-glucuronosyltransferase 1A1 (UGT1A1), one of the most essential conjugative enzymes, is responsible for the metabolism and detoxification of bilirubin and other endogenous substances, as well as many different xenobiotic compounds. Deciphering UGT1A1 relevance to human diseases and cha...