Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats

• Main Authors: Nakagawa Takayuki (Author), Shirakawa Hisashi (Author), Yatani Yumi (Author), Kawamoto Ai (Author), Maeda Sanae (Author), Kaneko Shuji (Author)
• Format: Book
• Published: SAGE Publishing, 2008-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The glial glutamate transporter GLT-1 is abundantly expressed in astrocytes and is crucial for glutamate removal from the synaptic cleft. Decreases in glutamate uptake activity and expression of spinal glutamate transporters are repo...