Evaluation of the Protective Effects of Cyclosporin A and FK506 on Abnormal Cytosolic and Mitochondrial Ca2+ Dynamics During Ischemia and Exposure to High Glutamate Concentration in Mouse Brain Slice Preparations

• Main Authors: Tomoharu Yokoyama (Author), Tadashi Tanoue (Author), Erika Hasegawa (Author), Yukio Ikeda (Author), Shouichi Ohta (Author), Akibumi Omi (Author), Yoshihisa Kudo (Author), Hiroyuki Uchino (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the protective effects of the immunosuppressants cyclosporin A (CsA) and FK506 on abnormal cytosolic Ca2+ ([Ca2+]c) and mitochondrial Ca2+ concentration ([Ca2+]m) dynamics induced by ischemia or high l-glutamate concentration in mouse brain slice preparations. We used fura-4F and rhod-2...