Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species

• Main Authors: Zhifan Mao (Author), Wenwen Liu (Author), Yunyuan Huang (Author), Tianyue Sun (Author), Keting Bao (Author), Jiali Feng (Author), Alexey Moskalev (Author), Zelan Hu (Author), Jian Li (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sulfonylureas are widely used oral anti-diabetic drugs. However, its long-term usage effects on patients' lifespan remain controversial, with no reports of influence on animal longevity. Hence, the anti-aging effects of chlorpropamide along with glimepiride, glibenclamide, and tolbutamide were...