Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 Patients

• Main Authors: Miao Zhang (Author), Xueting Yao (Author), Zhe Hou (Author), Xuan Guo (Author), Siqi Tu (Author), Zihan Lei (Author), Zhiheng Yu (Author), Xuanlin Liu (Author), Cheng Cui (Author), Xijing Chen (Author), Ning Shen (Author), Chunli Song (Author), Jie Qiao (Author), Xiaoqiang Xiang (Author), Haiyan Li (Author), Dongyang Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In Feb 2020, we developed a physiologically-based pharmacokinetic (PBPK) model of hydroxychloroquine (HCQ) and integrated in vitro anti-viral effect to support dosing design of HCQ in the treatment of COVID-19 patients in China. This, along with emerging research and clinical findings, supported bro...