Hypomyelinating Leukodystrophy 10 (HLD10)-Associated Mutations of PYCR2 Form Large Size Mitochondria, Inhibiting Oligodendroglial Cell Morphological Differentiation

• Main Authors: Tomohiro Torii (Author), Remina Shirai (Author), Risa Kiminami (Author), Satoshi Nishino (Author), Takanari Sato (Author), Sui Sawaguchi (Author), Nana Fukushima (Author), Yoichi Seki (Author), Yuki Miyamoto (Author), Junji Yamauchi (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypomyelinating leukodystrophy 10 (HLD10) is an autosomal recessive disease related to myelin sheaths in the central nervous system (CNS). In the CNS, myelin sheaths are derived from differentiated plasma membranes of oligodendrocytes (oligodendroglial cells) and surround neuronal axons to achieve n...