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Inhibition of CYP1A1 by pharmaceutical drugs, omeprazol and ketoconazole as a mechanism for activation of aryl hydrocarbon receptor (AHR)

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Omeprazole (OMP) and ketoconazole (KTZ) have been shown to activate the AHR signaling pathway in spite of the fact that they bind to the receptor with low or no affinity. The aim of this study was to investigate whether KTZ and OMP can act as indirect activator of AHR. In order to evaluate the effec...

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Main Authors: Ali Ghaffarian-Bahraman (Author), Nilofar Sadeghimanesh (Author), Mona Mirzaei (Author), Amin-Reza Akbarizadeh (Author), Mahmoud Omidi (Author), Hamidreza Mohammadi (Author), Mohammad-Reza Arabnezhad (Author), Keivan Mobini (Author), Afshin Mohammadi-Bardbori (Author)
Format: Book
Published: Shiraz University of Medical Sciences, 2017-03-01T00:00:00Z.
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