Effects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast

• Main Authors: Jing Bi (Author), Robert T. Carroll (Author), Michael L. James (Author), Jessica L. Ouderkirk (Author), Mira Krendel (Author), Vladimir Sirotkin (Author)
• 格式: 图书
• 出版: The Company of Biologists, 2015-08-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Point mutations in the human MYO1E gene, encoding class I myosin Myo1e, are associated with focal segmental glomerulosclerosis (FSGS), a primary kidney disorder that leads to end-stage kidney disease. In this study, we used a simple model organism, fission yeast Schizosaccharomyces pombe, to test th...