A Minimal Physiologically‐Based Pharmacokinetic Model for Tacrolimus in Living‐Donor Liver Transplantation: Perspectives Related to Liver Regeneration and the cytochrome P450 3A5 (CYP3A5) Genotype

• Main Authors: Kotaro Itohara (Author), Ikuko Yano (Author), Tetsunori Tsuzuki (Author), Miwa Uesugi (Author), Shunsaku Nakagawa (Author), Atsushi Yonezawa (Author), Hideaki Okajima (Author), Toshimi Kaido (Author), Shinji Uemoto (Author), Kazuo Matsubara (Author)
• Format: Book
• Published: Wiley, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In adult patients after living‐donor liver transplantation, postoperative days and the cytochrome P450 3A5 (CYP3A5) genotype are known to affect tacrolimus pharmacokinetics. In this study, we constructed a physiologically‐based pharmacokinetic model adapted to the clinical data and evaluated the con...