Systemic TNF-α blockade attenuates anxiety and depressive-like behaviors in db/db mice through downregulation of inflammatory signaling in peripheral immune cells

• Main Authors: Musaad A. Alshammari (Author), Mohammad R. Khan (Author), Hafiz Majid Mahmood (Author), Abdulaziz O. Alshehri (Author), Fawaz F. Alasmari (Author), Faleh M. Alqahtani (Author), Abdullah F. Alasmari (Author), Shakir D. Alsharari (Author), Abdulaziz Alhossan (Author), Sheikh F. Ahmad (Author), Ahmed Nadeem (Author), Tahani K. Alshammari (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Research studies have indicated that the comorbidity burden of mood disorders and obesity is reasonably high. Insulin signaling has been shown to modulate multiple physiological functions in the brain, indicating its association with neuropsychiatric diseases, including mood disorders. Leptin is a h...