Understanding the Role of Sodium Lauryl Sulfate on the Biorelevant Solubility of a Combination of Poorly Water-Soluble Drugs Using High Throughput Experimentation and Mechanistic Absorption Modeling

Understanding the Role of Sodium Lauryl Sulfate on the Biorelevant Solubility of a Combination of Poorly Water-Soluble Drugs Using High Throughput Experimentation and Mechanistic Absorption Modeling

This study investigates the influence of surfactant sodium lauryl sulfate (SLS) on the solubility of poorly-water soluble drug substances, model Compound X and Compound Y, used in a fixed dose combination oral solid dosage form. To determine the impact of SLS concentration on the solubility of compo...

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Main Authors: Matthew Nathan Bahr (Author), Dimple Modi (Author), Sarsvatkumar Patel (Author), Gossett Campbell (Author), Gregory Stockdale (Author)
Format: Book
Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
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