Synthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates

• Main Authors: Lianqi Liu (Author), Fei Xie (Author), Dian Xiao (Author), Xin Xu (Author), Zheng Su (Author), Yanming Wang (Author), Shiyong Fan (Author), Xinbo Zhou (Author), Song Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Camptothecins, traditional chemotherapy drugs, have been clinically used in antibody-drug conjugates (ADCs), which refreshes the recognition that ADCs preferably incorporate highly potent payloads. However, SN-38, active metabolite of irinotecan from camptothecins, tended to be incorporated into ADC...