A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters.

• Main Authors: Neeltje van Doremalen (Author), Teresa Lambe (Author), Sarah Sebastian (Author), Trenton Bushmaker (Author), Robert Fischer (Author), Friederike Feldmann (Author), Elaine Haddock (Author), Michael Letko (Author), Victoria A Avanzato (Author), Ilona Rissanen (Author), Rachel LaCasse (Author), Dana Scott (Author), Thomas A Bowden (Author), Sarah Gilbert (Author), Vincent Munster (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syr...