Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies

• Main Authors: Jakob C. Stüber (Author), Karin F. Rechberger (Author), Saša M. Miladinović (Author), Thomas Pöschinger (Author), Tamara Zimmermann (Author), Remi Villenave (Author), Miro J. Eigenmann (Author), Thomas E. Kraft (Author), Dhaval K. Shah (Author), Hubert Kettenberger (Author), Wolfgang F. Richter (Author)
• Format: Book
• Published: SpringerOpen, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This study explores the impact of antibody surface charge on tissue distribution into various tissues including tumor. Tumor-bearing mice were dosed intravenously with a mixture comprising three antibodies engineered to carry negative charge patches, a balanced charge distribution, or posit...