Characterizing ABC-Transporter Substrate-Likeness Using a Clean-Slate Genetic Background

• Príomhchruthaitheoirí: Artem Sokolov (Údar), Stephanie Ashenden (Údar), Nil Sahin (Údar), Richard Lewis (Údar), Nurdan Erdem (Údar), Elif Ozaltan (Údar), Andreas Bender (Údar), Frederick P. Roth (Údar), Murat Cokol (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Mutations in ATP Binding Cassette (ABC)-transporter genes can have major effects on the bioavailability and toxicity of the drugs that are ABC-transporter substrates. Consequently, methods to predict if a drug is an ABC-transporter substrate are useful for drug development. Such methods traditionall...