Characterizing ABC-Transporter Substrate-Likeness Using a Clean-Slate Genetic Background

• Главные авторы: Artem Sokolov (Автор), Stephanie Ashenden (Автор), Nil Sahin (Автор), Richard Lewis (Автор), Nurdan Erdem (Автор), Elif Ozaltan (Автор), Andreas Bender (Автор), Frederick P. Roth (Автор), Murat Cokol (Автор)
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• Опубликовано: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Предметы: article
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Mutations in ATP Binding Cassette (ABC)-transporter genes can have major effects on the bioavailability and toxicity of the drugs that are ABC-transporter substrates. Consequently, methods to predict if a drug is an ABC-transporter substrate are useful for drug development. Such methods traditionall...