Characterizing ABC-Transporter Substrate-Likeness Using a Clean-Slate Genetic Background

• Main Authors: Artem Sokolov (Author), Stephanie Ashenden (Author), Nil Sahin (Author), Richard Lewis (Author), Nurdan Erdem (Author), Elif Ozaltan (Author), Andreas Bender (Author), Frederick P. Roth (Author), Murat Cokol (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in ATP Binding Cassette (ABC)-transporter genes can have major effects on the bioavailability and toxicity of the drugs that are ABC-transporter substrates. Consequently, methods to predict if a drug is an ABC-transporter substrate are useful for drug development. Such methods traditionall...