Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells

• Автори: Chutamas Thepmalee (Автор), Aussara Panya (Автор), Jatuporn Sujjitjoon (Автор), Nunghathai Sawasdee (Автор), Naravat Poungvarin (Автор), Mutita Junking (Автор), Pa-Thai Yenchitsomanus (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2020-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that inhib...