Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells

• Main Authors: Chutamas Thepmalee (Author), Aussara Panya (Author), Jatuporn Sujjitjoon (Author), Nunghathai Sawasdee (Author), Naravat Poungvarin (Author), Mutita Junking (Author), Pa-Thai Yenchitsomanus (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that inhib...