The Effect of BAFF Inhibition on Autoreactive B-Cell Selection in Murine Systemic Lupus Erythematosus

• Main Authors: Alexis Boneparth (Author), Megan Woods (Author), Weiqing Huang (Author), Meredith Akerman (Author), Martin Lesser (Author), Anne Davidson (Author)
• Format: Book
• Published: BMC, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF) availability influences selection of the autoreactive B-cell repertoire in NZB/W and NZW/BXSB lupus-prone mice bearing the site-directed heavy-chain transgene 3H9 that encodes for anti-dsDNA and an...