Enhancement of paclitaxel transport and cytotoxicity by 7,3',4'-trimethoxyflavone, a P-glycoprotein inhibitor

Purpose.: Paclitaxel has problems with respect to bioavailability and resistance. The aim of this study was to select a P-glycoprotein (Pgp)- inhibitory flavonoid to enhance paclitaxel bioavailability in the Caco-2 cell monolayer. Methods. Cytotoxicity and chemosensitization were determined using MT...

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Autores principales: Ju-Mi Jeong (Autor), Cheol-Hee Choi (Autor)
Formato: Libro
Publicado: Frontiers Media S.A., 2007-10-01T00:00:00Z.
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Número de Clasificación: A1234.567
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