Enhanced IL-34 expression in Nivolumab-resistant metastatic melanoma

• Main Authors: Nanumi Han (Author), Muhammad Baghdadi (Author), Kozo Ishikawa (Author), Hiraku Endo (Author), Takuto Kobayashi (Author), Haruka Wada (Author), Keisuke Imafuku (Author), Hiroo Hata (Author), Ken-ichiro Seino (Author)
• Format: Book
• Published: BMC, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Immunotherapies that target immune-checkpoint molecules such PD-1 have helped to achieve durable responses in melanoma treatment. However, 25% of melanoma patients who showed objective responses to PD-1 blockade develop resistance and suffer from disease progression and ultimatel...