Physicochemical, Pharmacokinetic, and Toxicity Evaluation of Soluplus^® Polymeric Micelles Encapsulating Fenbendazole

• Main Authors: Ik Sup Jin (Author), Min Jeong Jo (Author), Chun-Woong Park (Author), Youn Bok Chung (Author), Jin-Seok Kim (Author), Dae Hwan Shin (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fenbendazole (FEN), a broad-spectrum benzimidazole anthelmintic, suppresses cancer cell growth through various mechanisms but has low solubility and achieves low blood concentrations, which leads to low bioavailability. Solubilizing agents are required to prepare poorly soluble drugs for injections;...