Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich's ataxia

• Main Authors: Amandine Palandri (Author), Elodie Martin (Author), Maria Russi (Author), Michael Rera (Author), Hervé Tricoire (Author), Véronique Monnier (Author)
• Format: Book
• Published: The Company of Biologists, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Friedreich's ataxia (FA) is caused by reduced levels of frataxin, a highly conserved mitochondrial protein. There is currently no effective treatment for this disease, which is characterized by progressive neurodegeneration and cardiomyopathy, the latter being the most common cause of death in...