Preparation and Characterization of Amorphous Solid Dispersions for the Solubilization of Fenretinide

• Main Authors: Guendalina Zuccari (Author), Eleonora Russo (Author), Carla Villa (Author), Alessia Zorzoli (Author), Danilo Marimpietri (Author), Leonardo Marchitto (Author), Silvana Alfei (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fenretinide (4-HPR), a retinoid derivative, has shown high antitumor activity, a low toxicological profile, and no induction of resistance. Despite these favorable features, the variability in oral absorption due to its low solubility combined with the high hepatic first pass effect strongly reduce...