Preparation and Characterization of Amorphous Solid Dispersions for the Solubilization of Fenretinide

• Asıl Yazarlar: Guendalina Zuccari (Yazar), Eleonora Russo (Yazar), Carla Villa (Yazar), Alessia Zorzoli (Yazar), Danilo Marimpietri (Yazar), Leonardo Marchitto (Yazar), Silvana Alfei (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2023-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Fenretinide (4-HPR), a retinoid derivative, has shown high antitumor activity, a low toxicological profile, and no induction of resistance. Despite these favorable features, the variability in oral absorption due to its low solubility combined with the high hepatic first pass effect strongly reduce...