Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

• Main Authors: Angelika Alonso (Author), Eileen Reinz (Author), Barbara Leuchs (Author), Jürgen Kleinschmidt (Author), Marc Fatar (Author), Bart Geers (Author), Ine Lentacker (Author), Michael G. Hennerici (Author), Stefaan C. de Smedt (Author), Stephen Meairs (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Delivery of drugs and macromolecules to the central nervous system (CNS) is hindered by the blood-brain barrier (BBB). Several approaches have been used to overcome this hindrance to facilitate the treatment of various CNS diseases. We now present results showing that chimeric adeno-associated virus...