Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening
Delivery of drugs and macromolecules to the central nervous system (CNS) is hindered by the blood-brain barrier (BBB). Several approaches have been used to overcome this hindrance to facilitate the treatment of various CNS diseases. We now present results showing that chimeric adeno-associated virus...
Saved in:
Main Authors: | Angelika Alonso (Author), Eileen Reinz (Author), Barbara Leuchs (Author), Jürgen Kleinschmidt (Author), Marc Fatar (Author), Bart Geers (Author), Ine Lentacker (Author), Michael G. Hennerici (Author), Stefaan C. de Smedt (Author), Stephen Meairs (Author) |
---|---|
Format: | Book |
Published: |
Elsevier,
2013-01-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
AAV2 and AAV9 tropism and transgene expression in the mouse eye and major tissues after intravitreal and subretinal delivery
by: Sanna Koponen, et al.
Published: (2023) -
Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa
by: Cia-Hin Lau, et al.
Published: (2019) -
Enhanced transgene expression from single-stranded AAV vectors in human cells in vitro and in murine hepatocytes in vivo
by: Yuan Lu, et al.
Published: (2024) -
Facilitation of Drug Transport across the Blood-Brain Barrier with Ultrasound and Microbubbles
by: Stephen Meairs
Published: (2015) -
Engineered AAV2.7m8 Serotype Shows Significantly Higher Transduction Efficiency of ARPE-19 and HEK293 Cell Lines Compared to AAV5, AAV8 and AAV9 Serotypes
by: Dzerassa Gurtsieva, et al.
Published: (2024)